When medications alone don’t suffice… what’s next for patients with resistant hypertension? Renal denervation therapy is an interventional blood pressure management technique that involves electrically neutralising the blood vessels to the kidneys since they are found to be the main cause of high blood pressure. When is renal denervation therapy recommended? Patients who have tried 2 or 3 BP medications with no results or the ones that react adversely to the medications are often recommended renal therapy by the heart specialists.