Monobenzone, the active ingredient in Benoquin 60%, works by permanently removing melanin from the skin. It enters the melanocytes (pigment-producing cells) and destroys them, which means the depigmentation is irreversible. While this may sound intimidating, for many patients with extensive vitiligo, it’s a welcome solution. Here’s a step-by-step breakdown: Penetration: The cream penetrates the outer layer of the skin to reach the melanocytes. Melanocyte Disruption: It disrupts the production and storage of melanin. Cell Destruction: Over time, the melanocytes are destroyed, leading to depigmentation. Maintenance: Continued use ensures a uniform skin tone and prevents re-pigmentation. This mechanism is what makes Benoquin 60% so effective and a preferred choice for those who opt for full depigmentation.