Differences Between Birthstones For April: Diamond vs Sapphire The exploration of the 5 main differences between birthstones for April, Diamonds vs Sapphires can surely fascinate April-born people with their unique qualities and therapeutic power. Both these gemstones for April differ in many ways including symbolism, history, origins, colors, and meaning but as birthstones, these crystals have a similar purpose to heal you from problematic situations.