Best Neighborhoods for a Safe Stay in New Orleans New Orleans, known for its vibrant culture and rich history, offers several safe neighborhoods ideal for visitors. The Garden District is popular for its beautiful mansions, tree-lined streets, and low crime rate. The French Quarter, while bustling, is well-patrolled and safe in the tourist-heavy areas, especially during the day. Uptown, home to Tulane University, has a family-friendly atmosphere with numerous parks and restaurants. Marigny and Bywater are trendy, artsy areas with a close-knit community feel, also considered safe for visitors. Each of these neighborhoods offers unique charm while providing a secure environment.