Creatinine levels in diabetes Often diabetic people experience a sudden jump in creatinine levels. Kidney damage due to diabetes progresses through different stages and one important stage is the new onset of hypertension in diabetic people. When the pressure levels are not constantly monitored, this increase in pressure levels will cause a jump in creatinine levels. Watch Dr. R. Kishor Kumar of Kauvery Hospital, one of the best nephrologists in Salem talk about the relationship between creatinine levels and diabetes management.