Biofreeze Pain Relief Roll On Gel 82g Biofreeze helps provide effective relief for people troubled by sore muscles and muscle sprains, back, shoulder and neck pain, arthritis, painful ankle, knee, hip and elbow joints, and muscular strains. In addition, Biofreeze can help to treat the pain associated with such conditions and symptoms as diabetic neuropathy, tendonitis, bursitis, plantar fasciitis and others.