An acute overdose of nonsteroidal anti-inflammatory drugs (NSAIDs) can result in a range of symptoms, including apathy, drowsiness, nausea, vomiting, and upper abdominal pain (epigastric pain). Fortunately, these symptoms are generally reversible through appropriate medical treatment and intervention. However, it is crucial to remain vigilant about potential complications, particularly gastrointestinal bleeding, which can be a severe consequence of NSAID overdose. Therefore, if you suspect that you or someone else has taken an overdose of NSAIDs or if you experience any worrisome symptoms after using NSAIDs, it is imperative to seek prompt medical assistance.